Association between tumor 18F-fluorodeoxyglucose metabolism and survival in women with estrogen receptor-positive, HER2-negative breast cancer.

Abstract

We examined whether 18F-fluorodeoxyglucose metabolism is associated with distant relapse-free survival (DRFS) and overall survival (OS) in women with estrogen receptor (ER)-positive, HER2-negative breast cancer. This was a cohort study examining the risk factors for survival that had occurred at the start of the study. A cohort from Asan Medical Center, Korea, recruited between November 2007 and December 2014, was included. Patients received anthracycline-based neoadjuvant chemotherapy. The maximum standardized uptake value (SUV) of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) was measured. The analysis included 466 women. The median (interquartile range) follow-up period without distant metastasis or death was 6.2 (5.3-7.6) years. Multivariable analysis of hazard ratio (95% confidence interval [CI]) showed that the middle and high tertiles of SUV were prognostic for DRFS (2.93, 95% CI 1.62-5.30; P < 0.001) and OS (4.87, 95% CI 1.94-12.26; P < 0.001). The 8-year DRFS rates were 90.7% (95% CI 85.5-96.1%) for those in the low tertile of maximum SUV vs. 73.7% (95% CI 68.0-79.8%) for those in the middle and high tertiles of maximum SUV. 18F-fluorodeoxyglucose PET/CT may assess the risk of distant metastasis and death in ER-positive, HER2-negative patients.

• Authors: Sun Young Chae, Seol Hoon Park, Hyo Sang Lee, Jin-Hee Ahn, Sung-Bae Kim, Kyung Hae Jung, Jeong Eun Kim, Sei Hyun Ahn, Byung Ho Son, Jong Won Lee, Beom Seok Ko, Hee Jeong Kim, Gyungyub Gong, Jungsu S Oh, Seo Young Park, Dae Hyuk Moon
• Journal: Scientific reports (Sci Rep) Vol. 12 Issue 1 Pg. 7858 (05 12 2022) ISSN: 2045-2322 [Electronic] England
• PMID: 35552460 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2022. The Author(s).

Chemical References

• Radiopharmaceuticals
• Receptors, Estrogen
• Fluorodeoxyglucose F18

Topics

• Breast Neoplasms (metabolism)
• Cohort Studies
• Female
• Fluorodeoxyglucose F18
• Humans
• Neoplasm Recurrence, Local (diagnostic imaging)
• Positron Emission Tomography Computed Tomography (methods)
• Positron-Emission Tomography
• Prognosis
• Radiopharmaceuticals (therapeutic use)
• Receptors, Estrogen (metabolism)