Abstract | BACKGROUND: METHODS: RESULTS: Sixty patients were investigated, of which 47% were male. Age at CMR and TOF repair was 15 years [interquartile range (IQR) 9, 22] and 3.2 months (IQR 0.8, 6.2), respectively. Twelve (20%) had prior pulmonary valve replacement (PVR). MMP1 values were higher among those with prior PVR (16.7 (IQR 7.9, 25.5) vs 14.4 (IQR 9.9, 24.9), p = 0.02). When stratifying MMP1 into low and high groups, higher MMP1 was associated with higher indexed right (RV) and left ventricular (LV) mass and RV mass:volume ratios after adjusting for PVR. No other associations between biomarkers and CMR parameters were identified. CONCLUSIONS: Only MMP1 was associated with markers of RV remodeling after TOF repair. As an enzyme involved in extracellular matrix degradation, MMP1 could be associated with fibrotic processes underlying RV remodeling, including dilation and hypertrophy. The additional biomarkers may not be specific towards cardiac remodeling. These findings merit further correlations with myocardial fibrosis measurements by CMR.
|
Authors | Michael P DiLorenzo, Grace DeCost, Anh Duc Mai, Nkecha Hughes, Elizabeth Goldmuntz, Andrea Jones, Mark A Fogel, Laura Mercer-Rosa |
Journal | International journal of cardiology
(Int J Cardiol)
Vol. 358
Pg. 27-33
(07 01 2022)
ISSN: 1874-1754 [Electronic] Netherlands |
PMID | 35487317
(Publication Type: Comparative Study, Journal Article)
|
Copyright | Copyright © 2022 Elsevier B.V. All rights reserved. |
Chemical References |
- Biomarkers
- MIRN21 microRNA, human
- MicroRNAs
- Matrix Metalloproteinase 1
|
Topics |
- Adult
- Biomarkers
- Cardiomyopathies
- Female
- Fibrosis
- Humans
- Magnetic Resonance Spectroscopy
- Male
- Matrix Metalloproteinase 1
- MicroRNAs
- Pulmonary Valve
(surgery)
- Pulmonary Valve Insufficiency
(surgery)
- Tetralogy of Fallot
(diagnostic imaging, surgery)
- Ventricular Function, Right
|