Moderately regulating vascularization and immune microenvironment of
wound site is necessary to achieve scarless wound healing of the skin. Herein, we have prepared an angiogenesis-promoting and
scar-preventing band-aid with a core-shell structure, that consists of
MXene-loaded nanofibers (MNFs) as the core and
dopamine-
hyaluronic acid hydrogel (H) as the shell (MNFs@V-H@DA) to encapsulate a
growth factor (
vascular endothelial growth factor,
VEGF, abbreviated as V) and H2S donor (
diallyl trisulfide, DATS, abbreviated as DA). The continuous release of DA from this system produced H2S, which would successfully induce macrophages to polarize into M2-lile phenotype, regulating the immune microenvironment and inhibiting an excessive inflammatory response at the
wound sites. It is conducive to the proliferation of skin cells, facilitating the wound healing. In addition, an appropriate amount of
VEGF can be released from the
MXene nanofibrous skeleton by adjusting the time of near-infrared (NIR) light exposure, preventing excessive neovascularization and extracellular matrix deposition at the
wound sites. Collectively, this NIR photothermal-responsive band-aid achieved scarless wound healing through gradient-controlled vascularization and a related immune sequential reaction of damaged skin tissue.