Diagnostic accuracy of 18F-PSMA-1007 PET/CT for prostate cancer in primary staging and biochemical recurrence with different serum PSA levels: A systematic review and meta-analysis.

Abstract

OBJECTIVE:

We performed a systematic review and meta-analysis to evaluate the application value of fluorine-18-prostate specific membrane antigen (18F-PSMA-1007) positron emission tomography/computed tomography (PET/CT) in patients with different serum prostate specific antigen (PSA) levels and primary prostate cancer (PCa) or the biochemical recurrence of PCa.

METHODS:

A comprehensive electronic literature search of the PubMed, Embase and Cochrane Library databases was conducted in accordance with the PRISMA statement. We calculated the pooled sensitivity and specificity of 18F-PSMA-1007 PET/CT in PCa. A summary receiver operator characteristic (SROC) curve and the area under the curve (AUC) were used to assess the accuracy of 18F-PSMA-1007 PET/CT for PCa.

RESULTS:

The final analysis included 11 studies that described 799 patients and 4261 lesions with 18F-PSMA-1007 PET/CT in PCa. The pooled sensitivity and specificity of 18F-PSMA-1007 PET/CT in PCa were 0.836 and 0.946, respectively. The per-patient pooled sensitivity and specificity of 18F-PSMA-1007 PET/CT in PCa were 0.934 and 0.453, and the per-lesion values were 0.816 and 0.979, respectively. The pooled sensitivity and specificity of 18F-PSMA-1007 PET/CT in PCa with PSA>2ng/mL were 0.923 and 0.442 in a patient-based analysis and 0.799 and 0.961 in a lesion-based analysis, respectively. The pooled sensitivity and specificity of 18F-PSMA-1007 PET/CT in PCa with PSA≤2ng/mL were 0.832 and 0.277 in a patient-based analysis, respectively.

CONCLUSION:

This meta-analysis showed that 18F-PSMA-1007 PET/CT has a higher diagnostic value for prostate cancer in the setting of primary PCa and biochemical recurrence. As serum PSA levels increase, the diagnostic accuracy of 18F-PSMA-1007 PET/CT also improves.

• Authors: Xue Liu, Qi Wang, Bao Zhang, Tao Jiang, Wenbing Zeng
• Journal: Hellenic journal of nuclear medicine (Hell J Nucl Med) 2022 Jan-Apr Vol. 25 Issue 1 Pg. 88-102 ISSN: 1790-5427 [Print] Greece
• PMID: 35388806 (Publication Type: Journal Article, Meta-Analysis, Systematic Review)

Chemical References

• Gallium Radioisotopes
• Oligopeptides
• PSMA-1007
• Niacinamide
• Prostate-Specific Antigen

Topics

• Gallium Radioisotopes
• Humans
• Male
• Niacinamide (analogs & derivatives)
• Oligopeptides
• Positron Emission Tomography Computed Tomography (methods)
• Prostate-Specific Antigen
• Prostatic Neoplasms (diagnostic imaging, pathology)