Effects of nalbuphine on the cardiotoxicity of ropivacaine in rats.

Abstract

When combined with nalbuphine, local anesthetics show a longer duration of nerve block without increasing complications. However, no evidence is available concerning the effect of nalbuphine on the cardiotoxicity of local anesthetics. The objective of this work is to investigate whether nalbuphine pretreatment can increase the lethal dose threshold of ropivacaine in rats. Anesthetized Sprague Dawley rats were pretreated with different doses of nalbuphine (0.4, 0.8, 1.5, 3.0, 5.0 mg/kg) or NS (normal saline, negative control) or 30% LE (lipid emulsion, positive control) 2 ml/kg/min for 5 min (n = 6). Then 0.5% ropivacaine was infused at a rate of 2.5 mg/kg/min until asystole occurs. Time of arrhythmia, 50% mean arterial pressure- and 50% heart rate-reduction, and asystole were recorded, and ropivacaine doses were calculated. Nalbuphine (0.4-5.0 mg/kg) did not affect ropivacaine-induced arrhythmia, 50% mean arterial pressure-reduction and 50% heart rate-reduction, and asystole in rats compared with NS pre-treatment. The asystole dose threshold (in milligrams per kilogram) of group LE was higher than that of group NS (NS 28.25(6.32) vs. LE, 41.58(10.65); P = 0.04; 95% confidence interval 0.23 to 26.45), while thresholds of arrhythmia, 50% mean arterial pressure-reduction, and 50% heart rate-reduction were not affected by LE. Nalbuphine doses of 0.4-5.0 mg/kg pretreatment did not increase the threshold of ropivacaine cardiotoxicity compared with NS control; 30% LE increases the lethal dose threshold of ropivacaine in rats.

• Authors: Chenran Wang, Shen Sun, Jing Jiao, Xinhua Yu, Shaoqiang Huang
• Journal: Fundamental & clinical pharmacology (Fundam Clin Pharmacol) Vol. 36 Issue 5 Pg. 811-817 (Oct 2022) ISSN: 1472-8206 [Electronic] England
• PMID: 35373856 (Publication Type: Journal Article)
• Copyright: © 2022 Société Française de Pharmacologie et de Thérapeutique.

Chemical References

• Amides
• Anesthetics, Local
• Ropivacaine
• Nalbuphine
• Bupivacaine

Topics

• Amides (toxicity)
• Anesthetics, Local (toxicity)
• Animals
• Arrhythmias, Cardiac (chemically induced)
• Bupivacaine
• Cardiotoxicity (etiology)
• Heart Arrest (chemically induced)
• Nalbuphine (toxicity)
• Rats
• Rats, Sprague-Dawley
• Ropivacaine (toxicity)