Rhabdomyosarcoma, a common soft tissue malignant
tumor in children and adolescents, is exceedingly rare in adults. Nevertheless, The outcome in adults is very poor, especially when compared to outcomes in children in whom significant improvements in treatment has been achieved. The first case was of a 24-year-old pregnant Chinese woman with a rare primary site of
rhabdomyosarcoma in the perineal body. She presented with a perineal mass and was diagnosed during the second trimester of pregnancy, which is a very rare occurrence. The second case was a 70-year-old Chinese woman who suffered from right lower
abdominal pain for 1 month and was misdiagnosed with an
epithelial ovarian carcinoma. Mesenteric pleomorphic
rhabdomyosarcoma was later confirmed by postoperative pathology. Both cases had undergone preoperative examination with chest and abdominal computed tomography (CT) and pelvic magnetic resonance imaging (MRI) examinations, as well as examination of complete blood count, liver panel, renal panel, and serum
tumor markers. Diagnosis was based on histopathology and immunohistochemistry. The patient in the first case received
chemotherapy after which the mass decreased in size; however, the patient was lost to follow-up. The second case underwent
tumor resection and received
chemotherapy and
radiotherapy.