Association of Matrix Metallopeptidase-2 Genotypes With Risk of Gastric Cancer in Taiwan.

Abstract

BACKGROUND/AIM:

Matrix metalloproteinase-2 (MMP-2) plays a critical role in the regulation of the extracellular matrix; however, its genotypes have seldom been examined in gastric cancer (GC). This study aimed to investigate the contribution of MMP-2 promoter -1306 (rs243865) and -735 (rs2285053) genotypes to GC risk in a cohort of Taiwanese individuals.

MATERIALS AND METHODS:

This study included 121 GC cases and 363 age- and sex-matched controls. The genotypes of MMP-2 were determined by typical polymerase chain reaction-restriction fragment length polymorphism.

RESULTS:

The genotypic and allelic frequency analysis showed that MMP-2 rs243865 variant genotypes decreased the risk of GC. Stratification analysis showed that MMP-2 rs243865 genotypes associate with smoking, alcohol drinking, and Helicobacter pylori infection status to confer personal susceptibility to GC. There is no such association for MMP-2 rs2285053 genotype with GC risk.

CONCLUSION:

The MMP-2 rs243865 genotypes may serve as a novel predictive marker for GC personal susceptibility among Taiwanese.

• Authors: Chun-Kai Fu, Mei-Chin Mong, Chien-Chih Yu, Mei-Due Yang, Zhi-Hong Wang, Ya-Chen Yang, Jaw-Chyun Chen, Jen-Sheng Pei, Ning-Yi Hsia, Chia-Wen Tsai, Wen-Shin Chang, DA-Tian Bau
• Journal: Anticancer research (Anticancer Res) Vol. 42 Issue 4 Pg. 1749-1755 (04 2022) ISSN: 1791-7530 [Electronic] Greece
• PMID: 35346993 (Publication Type: Journal Article)
• Copyright: Copyright © 2022 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Chemical References

• MMP2 protein, human
• Matrix Metalloproteinase 2

Topics

• Case-Control Studies
• Genetic Predisposition to Disease
• Genotype
• Helicobacter Infections (complications)
• Humans
• Matrix Metalloproteinase 2 (genetics)
• Polymorphism, Single Nucleotide
• Risk Factors
• Stomach Neoplasms (epidemiology, genetics)
• Taiwan (epidemiology)