FTO in cancer: functions, molecular mechanisms, and therapeutic implications.

Abstract

N6-methyladenosine (m6A) is the most abundant internal modification in mRNA that affects RNA processing, stability, and translation. Discovered as the first RNA m6A demethylase, the fat mass and obesity-associated protein (FTO) is frequently dysregulated and plays important roles in various types of cancers. Targeting FTO holds promising therapeutic significance via suppressing tumor growth, potentiating immunotherapy, and attenuating drug resistance. Here, we review recent advances in our understanding of the functions and underlying molecular mechanisms of FTO in tumor development, cancer stem cell (CSC) self-renewal, microenvironment regulation, immunity, and metabolism and discuss the therapeutic potential of targeting FTO for cancer treatment.

• Authors: Yangchan Li, Rui Su, Xiaolan Deng, Yong Chen, Jianjun Chen
• Journal: Trends in cancer (Trends Cancer) Vol. 8 Issue 7 Pg. 598-614 (07 2022) ISSN: 2405-8025 [Electronic] United States
• PMID: 35346615 (Publication Type: Journal Article, Review, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural)
• Copyright: Copyright © 2022 Elsevier Inc. All rights reserved.

Chemical References

• RNA, Messenger
• RNA
• Alpha-Ketoglutarate-Dependent Dioxygenase FTO
• FTO protein, human
• Adenosine

Topics

• Adenosine (metabolism)
• Alpha-Ketoglutarate-Dependent Dioxygenase FTO (genetics, metabolism)
• Humans
• Neoplasms (drug therapy, genetics)
• RNA (metabolism)
• RNA, Messenger (genetics)
• Tumor Microenvironment (genetics)