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Effect of nighttime anisotropine methyl bromide of duodenal ulcer healing and pain: a double-blind controlled trial.

Abstract
Anisotropine methyl bromide, an anticholinergic, 80 mg given orally at 8 P.M., suppresses gastric acid secretion through the night without significant side effects. Thirty patients with endoscopy-proved symptomatic duodenal ulcer disease completed a randomized, double-blind, placebo-controlled trial of nighttime anisotropine methyl bromide therapy. Eleven (69 per cent) of 16 anisotropine methyl bromide-treated and six (43 per cent) of 14 placebo-treated subjects healed their ulcers within two weeks of starting treatment. The anisotropine methyl bromide-treated subjects averaged 0.63 +/- 0.27 (mean +/- S.E.) episodes of nocturnal pain during the treatment period versus 2.71 +/- 1.08 episodes in the placebo group (P = 0.06). This is the first reported study of this type designed to evaluate the efficacy of an anticholinergic agent in the healing of duodenal ulcers. Although not conclusive, the results suggest nighttime anisotropine methyl bromide therapy may be useful in the treatment of duodenal ulcer disease. Further studies seem warranted.
AuthorsJ H Bowers, J A Forbes, J W Freston
JournalJournal of clinical pharmacology (J Clin Pharmacol) Vol. 18 Issue 7 Pg. 365-71 (Jul 1978) ISSN: 0091-2700 [Print] UNITED STATES
PMID353090 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
Chemical References
  • Placebos
  • Tropanes
Topics
  • Adult
  • Clinical Trials as Topic
  • Double-Blind Method
  • Duodenal Ulcer (complications, drug therapy)
  • Female
  • Humans
  • Male
  • Middle Aged
  • Pain (drug therapy, etiology)
  • Placebos
  • Time Factors
  • Tropanes (therapeutic use)

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