Long-Term Clinical Impact of Contrast-Associated Acute Kidney Injury Following PCI: An ADAPT-DES Substudy.
Abstract | OBJECTIVES: BACKGROUND: METHODS: The ADAPT-DES (Assessment of Dual AntiPlatelet Therapy With Drug Eluting Stents) study was a prospective, multicenter registry of 8,582 patients treated with ≥1 drug-eluting stent(s). CA-AKI was defined as a post-PCI increase in serum creatinine of >0.5 mg/dL or a relative increase of ≥25% compared with pre-PCI. CKD was defined as estimated glomerular filtration rate <60 mL/min/1.73 m2. The primary endpoint was the 2-year rate of net adverse clinical events (NACE): All-cause mortality, myocardial infarction (MI), definite or probable stent thrombosis, or major bleeding. RESULTS: Of 7287 (85%) patients with evaluable data, 476 (6.5%) developed CA-AKI. In a multivariable model, older age, female sex, Caucasian race, congestive heart failure, diabetes, hypertension, CKD, presentation with ST-segment elevation MI, Killip class II to IV, radial access, intra-aortic balloon pump use, hypotension, and number of stents were independent predictors of CA-AKI. The 2-year NACE rate was higher in patients with CA-AKI (adjusted HR: 1.88; 95% CI: 1.42-2.49), as was each component of NACE (all-cause mortality, HR: 1.77; 95% CI: 1.22-2.55; MI, HR: 1.67; 95% CI: 1.18-2.36; definite/probable stent thrombosis, HR: 1.71; 95% CI: 1.10-2.65; and major bleeding, HR: 1.38; 95% CI: 1.06-1.80). Compared with the CA-AKI-/CKD- group, the CA-AKI+/CKD- (HR: 1.83; 95% CI: 1.33-2.52), CA-AKI-/CKD+ (HR: 1.56; 95% CI: 1.15-2.13), CA-AKI+/CKD+ (HR: 3.29; 95% CI: 1.92-5.67), and maintenance dialysis (HR: 2.67; 95% CI: 1.65-4.31) groups were at higher risk of NACE. CONCLUSIONS: CA-AKI was relatively common after contemporary PCI and was associated with increased 2-year rates of NACE. Patients with pre-existing CKD were at particularly high risk for NACE after CA-AKI.
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Authors | Reza Mohebi, Keyvan Karimi Galougahi, Javier Jas Garcia, Jennifer Horst, Ori Ben-Yehuda, Jai Radhakrishnan, Glenn M Chertow, Allen Jeremias, David J Cohen, David J Cohen, Akiko Maehara, Gary S Mintz, Shmuel Chen, Björn Redfors, Martin B Leon, Thomas D Stuckey, Michael J Rinaldi, Giora Weisz, Bernhard Witzenbichler, Ajay J Kirtane, Roxana Mehran, George D Dangas, Gregg W Stone, Ziad A Ali |
Journal | JACC. Cardiovascular interventions
(JACC Cardiovasc Interv)
Vol. 15
Issue 7
Pg. 753-766
(04 11 2022)
ISSN: 1876-7605 [Electronic] United States |
PMID | 35305904
(Publication Type: Journal Article, Multicenter Study)
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Copyright | Copyright © 2022 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved. |
Chemical References |
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Topics |
- Acute Kidney Injury
(chemically induced, diagnosis, epidemiology)
- Contrast Media
(adverse effects)
- Drug-Eluting Stents
- Female
- Hemorrhage
(chemically induced)
- Humans
- Male
- Myocardial Infarction
- Percutaneous Coronary Intervention
(adverse effects)
- Prospective Studies
- Renal Insufficiency, Chronic
(complications)
- Risk Factors
- Thrombosis
(etiology)
- Treatment Outcome
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