GelMA/PEGDA microneedles patch loaded with HUVECs-derived exosomes and Tazarotene promote diabetic wound healing.

Abstract

Clinical work and research on diabetic wound repair remain challenging globally. Although various conventional wound dressings have been continuously developed, the efficacy is unsatisfactory. The effect of drug delivery is limited by the depth of penetration. The sustained release of biomolecules from biological wound dressings is a promising treatment approach to wound healing. An assortment of cell-derived exosomes (exos) have been proved to be instrumental in tissue regeneration, and researchers are dedicated to developing biomolecules carriers with unique properties. Herein, we reported a methacrylate gelatin (GelMA) microneedles (MNs) patch to achieve transdermal and controlled release of exos and tazarotene. Our MNs patch comprising GelMA/PEGDA hydrogel has distinctive biological features that maintain the biological activity of exos and drugs in vitro. Additionally, its unique physical structure prevents it from being tightly attached to the skin of the wound, it promotes cell migration, angiogenesis by slowly releasing exos and tazarotene in the deep layer of the skin. The full-thickness cutaneous wound on a diabetic mouse model was carried out to demonstrate the therapeutic effects of GelMA/PEGDA@T + exos MNs patch. As a result, our GelMA/PEGDA@T + exos MNs patch presents a potentially valuable method for repairing diabetic wound in clinical applications.

• Authors: Meng Yuan, Kun Liu, Tao Jiang, Shengbo Li, Jing Chen, Zihan Wu, Wenqing Li, Rongzhi Tan, Wenying Wei, Xiaofan Yang, Honglian Dai, Zhenbing Chen
• Journal: Journal of nanobiotechnology (J Nanobiotechnology) Vol. 20 Issue 1 Pg. 147 (Mar 19 2022) ISSN: 1477-3155 [Electronic] England
• PMID: 35305648 (Publication Type: Journal Article)
• Copyright: © 2022. The Author(s).

Chemical References

• Nicotinic Acids
• tazarotene
• Gelatin

Topics

• Animals
• Diabetes Mellitus
• Exosomes
• Gelatin (pharmacology)
• Mice
• Nicotinic Acids
• Wound Healing