Applications of chemical exchange saturation transfer magnetic resonance imaging in identifying genetic markers in gliomas.

Abstract

Chemical exchange saturation transfer (CEST) imaging is an important molecular magnetic resonance imaging technique that can image numerous low-concentration biomolecules with water-exchangeable protons (such as cellular proteins) and tissue pH. CEST, or more specially amide proton transfer-weighted imaging, has been widely used for the detection, diagnosis, and response assessment of brain tumors, and its feasibility in identifying molecular markers in gliomas has also been explored in recent years. In this paper, after briefing on the basic principles and quantification methods of CEST imaging, we review its early applications in identifying isocitrate dehydrogenase mutation status, MGMT methylation status, 1p/19q deletion status, and H3K27M mutation status in gliomas. Finally, we discuss the limitations or weaknesses in these studies.

• Authors: Shanshan Jiang, Zhibo Wen, Sung Soo Ahn, Kejia Cai, Daniel Paech, Charles G Eberhart, Jinyuan Zhou
• Journal: NMR in biomedicine (NMR Biomed) Vol. 36 Issue 6 Pg. e4731 (06 2023) ISSN: 1099-1492 [Electronic] England
• PMID: 35297117 (Publication Type: Journal Article, Review, Research Support, N.I.H., Extramural)
• Copyright: © 2022 The Authors. NMR in Biomedicine published by John Wiley & Sons Ltd.

Chemical References

• Genetic Markers
• Protons
• Isocitrate Dehydrogenase

Topics

• Humans
• Genetic Markers
• Magnetic Resonance Imaging (methods)
• Glioma (diagnostic imaging, genetics, chemistry)
• Brain Neoplasms (diagnostic imaging, genetics, chemistry)
• Protons
• Isocitrate Dehydrogenase (genetics)