Successful Treatment of Systemic Sclerosis-related Pericarditis with Mycophenolate Mofetil and Low-dose Prednisolone.

Abstract

We herein report a case of systemic sclerosis (SSc)-related pericarditis successfully treated with mycophenolate mofetil (MMF) and low-dose prednisolone (PSL). The patient was a 72-year-old woman with anti-centromere antibody. Her clinical manifestations were Raynaud phenomenon, bilateral pleural effusion, pericardial effusion and skin tightness. Based on the findings of exudative pericardial effusion with the absence of pulmonary arterial hypertension from the results of the cardiac catheter and pericardiocentesis, she was diagnosed with SSc-related pericarditis and treated with PSL10 mg and MMF 1 g per day, leading to the complete resolution of pericarditis. These findings suggested that MMF and low-dose PSL were effective for SSc-related pericarditis.

• Authors: Kazuhiko Higashioka, Rioko Migita, Toshiyuki Ota, Ayumi Uchino, Hiroaki Niiro
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 61 Issue 20 Pg. 3125-3130 (Oct 15 2022) ISSN: 1349-7235 [Electronic] Japan
• PMID: 35283383 (Publication Type: Case Reports, Journal Article)

Chemical References

• Prednisolone
• Mycophenolic Acid

Topics

• Aged
• Female
• Humans
• Mycophenolic Acid (therapeutic use)
• Pericardial Effusion (drug therapy, etiology)
• Pericarditis (diagnosis, drug therapy, etiology)
• Prednisolone (therapeutic use)
• Scleroderma, Systemic (complications, drug therapy)