Actions of Bisphenol A on Different Feto-Maternal Compartments Contributing to Preterm Birth.

Abstract

Preterm birth remains to be one of the most prevalent obstetric complications worldwide. Since there are multiple etiological factors associated with this disease process, an integrative literature search in PubMed and Scopus databases on possible mechanism of action and effect of bisphenols on exposure on human or animal placental samples in preterm birth was conducted. From 2332 articles on initial literature search, 63 studies were included for full data extraction. Altogether, several pathways were shown to be possibly affected by bisphenols, leading to dysregulations in structural and endocrine foundation in the placenta, potential induction of senescence and failure of decidualization in the decidua, and possible propagation of inflammation in the fetal membranes. Combined, these actions may eventually counteract bisphenol-induced relaxation of the myometrium and promote contractility alongside fetal membrane weakening. In totality, these individual impairments in gestation-critical processes may lead to failure of maintenance of pregnancy, and thus effecting preterm birth.

• Authors: Manuel S Vidal Jr, Ramkumar Menon, Gracia Fe B Yu, Melissa D Amosco
• Journal: International journal of molecular sciences (Int J Mol Sci) Vol. 23 Issue 5 (Feb 22 2022) ISSN: 1422-0067 [Electronic] Switzerland
• PMID: 35269554 (Publication Type: Journal Article, Review)

Chemical References

• Benzhydryl Compounds
• Phenols
• bisphenol A

Topics

• Benzhydryl Compounds (adverse effects)
• Cellular Senescence (drug effects)
• Decidua (cytology, drug effects, metabolism)
• Female
• Gene Expression Regulation (drug effects)
• Humans
• Phenols (adverse effects)
• Pregnancy
• Premature Birth (chemically induced, metabolism)
• Signal Transduction (drug effects)