Triterpenoid Saponins From the Fruit of Acanthopanax senticosus (Rupr. & Maxim.) Harms.

Abstract

Five new oleanane-type triterpenoid saponins (1-5), together with 24 known saponins (6-29) were isolated from the fruit of Acanthopanax senticosus. Their structures were determined by extensive spectroscopic analysis, including 1D, 2D nuclear magnetic resonance (NMR), and high-resolution electrospray ionization mass spectrometry (HR-ESI-MS), in combination with chemical methods (acid hydrolysis). The neuroinflammation model was established by lipopolysaccharide (LPS)-induced BV2 microglia, and the neuroprotective effects of all compounds (1-29) were evaluated.

• Authors: Yan Liu, Peng Jiang, Mei-Ling Zhang, Juan Pan, Wei Guan, Xiao-Mao Li, Bing-You Yang, Hai-Xue Kuang
• Journal: Frontiers in chemistry (Front Chem) Vol. 10 Pg. 825763 ( 2022) ISSN: 2296-2646 [Print] Switzerland
• PMID: 35265584 (Publication Type: Journal Article)
• Copyright: Copyright © 2022 Liu, Jiang, Zhang, Pan, Guan, Li, Yang and Kuang.