Contemporary advances in antibody-mediated encephalitis: anti-LGI1 and anti-Caspr2 antibody (Ab)-mediated encephalitides.

Abstract	Encephalitides with antibodies directed against leucine-rich glioma-inactivated 1 (LGI1) and contactin-associated protein-like 2 (Caspr2) represent two increasingly well characterised forms of autoimmune encephalitis. Both share overlapping and distinct clinical features, are mediated by autoantibodies directed against differing proteins complexed with voltage-gated potassium channels, with unique genetic predisposition identified to date. Herein we summarise disease mechanisms, clinical features, treatment considerations, prognostic factors and clinical outcomes regarding these disorders.
Authors	Nabil Seery, Helmut Butzkueven, Terence J O'Brien, Mastura Monif
Journal	Autoimmunity reviews (Autoimmun Rev) Vol. 21 Issue 5 Pg. 103074 (May 2022) ISSN: 1873-0183 [Electronic] Netherlands
PMID	35247644 (Publication Type: Journal Article, Review)
Copyright	Copyright © 2022 Elsevier B.V. All rights reserved.
Chemical References	Autoantibodies Intracellular Signaling Peptides and Proteins anti-CASPR2 autoantibody Leucine
Topics	Autoantibodies Encephalitis (diagnosis, therapy) Glioma Humans Intracellular Signaling Peptides and Proteins Leucine

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