Selenium Supplementation Alters IL-1β and IL-6 Protein Levels in Contusion Model Rats.
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| Abstract |
<b>Background and Objective:</b> Contusion in skeletal muscles were common in athletes.<sup> </sup>Contusions usually occur when the tissue is exposed to a rapid and strong compressive force, for example, a direct blow, which usually results in the formation of a hematoma within the muscle. Contusion injuries impair the physiological function of the muscle. Supplementation is needed to shorten the healing process. Alternative therapy is antioxidant supplementation. Therefore, we conducted a study on the administration of the antioxidant selenium in contusion rats. <b>Materials and Methods:</b> The subject of this study were male Wistar rats. Rats were divided into 3 groups, namely control group, contusion group and selenium group. Each group consisted of 5 rats. Selenium dose was 0.0513 mg kg<sup>1</sup> b.wt., dissolved into 2% PGA given once a day, for 3 consecutive days. After treatment periods, CK-MM level, IL-1β and IL-6 level were examined. <b>Results:</b> Protein expression of IL-1β and IL-6 were significantly lower in the selenium treatment group compared to the contusion group. These results were confirmed by improved step gait in the selenium group. But there was no significant decrease in serum CK-MM levels expression in the selenium treatment group when compared to the contusion group. <b>Conclusion:</b> Selenium supplementation improved gait function after contusion by suppressing IL-1β and IL-6 expression. However, selenium administration did not alter CK-MM levels.
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| Authors | Hanna Goenawan, Mariel Daba, Vita Murniati Tarawan, Ronny Lesmana, Aziiz Mardanarian Rosdianto, Siti Nur Fatimah |
| Journal | Pakistan journal of biological sciences : PJBS (Pak J Biol Sci) Vol. 25 Issue 3 Pg. 226-233 (Jan 2022) ISSN: 1812-5735 [Electronic] Pakistan |
| PMID | 35234013 (Publication Type: Journal Article) |
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