Abstract | BACKGROUND: METHODS: After 24 h of controlled mechanical ventilation, subjects (PaO2 /FIO2 200-300 and PEEP level < 10 cm H2O) were randomized in sequence 1:1 by using a web-based encrypted platform and assigned to NAVA or variable PSV groups. Both modes of ventilation were consecutively kept for 24 h unless there were clinical changes. The primary aim of this study was to evaluate differences in asynchrony index (AI) between variable PSV and NAVA. Our secondary aims were to evaluate the coefficient of variation (CV) of breathing patterns and inspiratory effort between the groups. RESULTS: Thirteen subjects were randomized in the NAVA group and 13 subjects in the variable PSV group. AI over time and minute PTP (PTPmin) were not different between NAVA and variable PSV groups (AI t0P = .52, AI t12P = .27, AI t24P = .12; and PTPmin-t0P = .60, PTPmin-t12P = .57, PTPmin-t24P = .85, respectively). CV for tidal volume (VT) and pressure support (PS) was lower in variable PSV group over time compared with NAVA group (P < .05). CONCLUSIONS: In this randomized controlled trial including subjects with mild ARDS, NAVA and variable PSV had comparable effects on patient- ventilator synchronies and PTP. However, variable PSV reduced the variability of VT and PS when compared with NAVA.
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Authors | Maria Vargas, Pasquale Buonanno, Andrea Sica, Lorenzo Ball, Carmine Iacovazzo, Annachiara Marra, Paolo Pelosi, Giuseppe Servillo |
Journal | Respiratory care
(Respir Care)
Vol. 67
Issue 5
Pg. 503-509
(05 2022)
ISSN: 1943-3654 [Electronic] United States |
PMID | 35228305
(Publication Type: Journal Article, Randomized Controlled Trial)
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Copyright | Copyright © 2022 by Daedalus Enterprises. |
Topics |
- Humans
- Interactive Ventilatory Support
- Positive-Pressure Respiration
- Respiration
- Respiration, Artificial
- Respiratory Distress Syndrome
(therapy)
- Ventilators, Mechanical
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