Use of Pralsetinib as Neoadjuvant Therapy for Non-Small Cell Lung Cancer Patient With RET Rearrangement.

Abstract

RET rearrangements are rare, and occur in 1%-2% of all non-small cell lung cancer (NSCLC) patients. Pralsetinib has a significant anti-tumor effect in patients with advanced NSCLC and a RET rearrangement. Previous studies have confirmed the efficiency of neoadjuvant target therapy for NSCLC. Herein we present a case involving a female patient who was diagnosed with stage IIIA lung adenocarcinoma and harbored a KIF5B-RET rearrangement based on next-generation sequencing. Radiologic downstaging was indicated after pralsetinib treatment. Therefore, a right lower lobectomy and systemic lymphadenectomy were successfully performed. The postoperative pathologic results revealed a response rate of 74% for primary tumor and no residual viable tumor cells were observed in lymph nodes. The tumor, nodes, and metastases (TNM) stage was ypT1cN1M0. The tumor micro-environment (TME) of the primary tumor was also assessed.

• Authors: Ning Zhou, Tong Li, Maoli Liang, Fan Ren, Hong Ni, Wei Liu, Tao Shi, Dongbo Xu, Qiusong Chen, Haonan Yu, Zuoqing Song, Lingling Zu, Shuo Li, Song Xu
• Journal: Frontiers in oncology (Front Oncol) Vol. 12 Pg. 848779 ( 2022) ISSN: 2234-943X [Print] Switzerland
• PMID: 35223529 (Publication Type: Journal Article)
• Copyright: Copyright © 2022 Zhou, Li, Liang, Ren, Ni, Liu, Shi, Xu, Chen, Yu, Song, Zu, Li and Xu.