In vivo study for the hemostatic efficacy and foreign body reaction of a new powder-type polysaccharide hemostatic agent.

Abstract

PURPOSE:

Various hemostatic agents have been introduced in therapy as postoperative bleeding is a poor prognostic factor for postoperative outcomes. These products can be divided into those that directly promote the hemostatic cascade and those that physically form a barrier by absorbing blood. The latter, powder-type hemostatic agents have the advantages of being inexpensive and more absorbable with less foreign body reactions (FBRs) and are applicable to a relatively wide area. This study was conducted to verify the safety and efficacy of a newly invented polysaccharide product (OOZFIX, Theracion Biomedical), which improves blood absorption and hemostatic effects.

METHODS:

Two separate animal experiments were performed. The first evaluated FBRs histologically at 3 days, 2 weeks, and 4 weeks, after implantation of OOZFIX in rats, and the second compared hemostatic performance of OOZFIX and Arista AH (Bard) in the porcine liver punch biopsy model.

RESULTS:

We found minimal FBRs in the 3-day group and no reactions in both the 2-week and 4-week groups after implantation of hemostatic agents. The time to hemostasis of OOZFIX was not significantly different from that of Arista AH (median [interquartile range]: 9 [6-10] minutes vs. 8 [6-10] minutes, respectively; P = 0.522). When comparing the serial bleeding grade tendency, there was no statistical difference between OOZFIX and Arista AH (P = 0.656).

CONCLUSION:

OOZFIX caused a minimal FBR that disappeared within 2 weeks in vivo, and its hemostatic performance was comparable with that of an existing agent, Arista AH. Further clinical studies are required in the future.

• Authors: Yoonhyeong Byun, Eun Jin Kim, Areum Lee, Young-Ah Suh, Hee Ju Sohn, Jung Min Lee, Jae Seung Kang, Yoo Jin Choi, Youngmin Han, Hongbeom Kim, Wooil Kwon, Jin-Young Jang
• Journal: Annals of surgical treatment and research (Ann Surg Treat Res) Vol. 102 Issue 2 Pg. 65-72 (Feb 2022) ISSN: 2288-6575 [Print] Korea (South)
• PMID: 35198509 (Publication Type: Journal Article)
• Copyright: Copyright © 2022, the Korean Surgical Society.