Cytokine Receptors-Regulators of Antimycobacterial Immune Response.

Abstract

Cytokine receptors are critical regulators of the antimycobacterial immune response, playing a key role in initiating and coordinating the recruitment and activation of immune cells during infection. They recognize and bind specific cytokines and are involved in inducing intracellular signal transduction pathways that regulate a diverse range of biological functions, including proliferation, differentiation, metabolism and cell growth. Due to mutations in cytokine receptor genes, defective signaling may contribute to increased susceptibility to mycobacteria, allowing the pathogens to avoid killing and immune surveillance. This paper provides an overview of cytokine receptors important for the innate and adaptive immune responses against mycobacteria and discusses the implications of receptor gene defects for the course of mycobacterial infection.

• Authors: Magdalena Druszczyńska, Magdalena Godkowicz, Jakub Kulesza, Sebastian Wawrocki, Marek Fol
• Journal: International journal of molecular sciences (Int J Mol Sci) Vol. 23 Issue 3 (Jan 20 2022) ISSN: 1422-0067 [Electronic] Switzerland
• PMID: 35163035 (Publication Type: Journal Article, Review)

Chemical References

• Cytokines
• Receptors, Cytokine

Topics

• Adaptive Immunity
• Animals
• Cytokines (metabolism)
• Humans
• Immunity, Innate
• Mutation
• Mycobacterium Infections (genetics, immunology)
• Receptors, Cytokine (genetics, metabolism)
• Signal Transduction