Abstract | BACKGROUND: OBJECTIVE: We aim to investigate whether serum NGAL levels were associated with elevated risk of depressive symptoms in patients with type 2 DM in an old population. METHODS: Blood samples from 1012 hospitalized patients were measured for serum NGAL within the first 24 hours after admission. The Center for Epidemiological Studies Depression (CES-D) scale was performed to calculate depressive score. Cox analyses were used to examine the prognostic value of serum NGAL on detecting depressive symptoms during a median period of 5 years (range = 0.3-6.2 years). RESULTS: 136 (36.6)% of all subjects have depressive symptoms during the follow-up period. Linear analysis showed that serum NGAL levels at baseline were associated with CES-D score after adjusting for clinically relevant variables in type 2 DM patients (Sβ = 0.118, 95% CI 0.106-0.171, P < .001) but not in non-DM patients (Sβ = 0.025, 95% CI, -0.047-0.083; P = .205). Cox analysis revealed that serum NGAL did have an independent prognostic value on predicting depressive symptoms (HR = 2.247, 95% CI 1.415-3.811, P-trend<0.001, Model 2) in type 2 DM patients but not in non-DM patients (HR = 1.811, 95% CI 1.209-3.292, P-trend = 0.189, Model 2) during follow-up period. CONCLUSIONS: We found the first evidence that serum NGAL were strongly associated with depressive symptoms in patients with type 2 DM but not in non-DM patients. Further studies are needed to prove the underlying mechanism for the impact of type 2 DM on the association.
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Authors | Taihai Wang, Yue Liu, Wenwu Huang |
Journal | Experimental aging research
(Exp Aging Res)
2022 Oct-Dec
Vol. 48
Issue 5
Pg. 444-454
ISSN: 1096-4657 [Electronic] United States |
PMID | 35142261
(Publication Type: Journal Article)
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Chemical References |
- Acute-Phase Proteins
- Biomarkers
- Lipocalin-2
- Lipocalins
- Proto-Oncogene Proteins
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Topics |
- Acute-Phase Proteins
- Aging
- Biomarkers
- Depression
(etiology)
- Diabetes Mellitus, Type 2
(complications)
- Humans
- Lipocalin-2
- Lipocalins
- Proto-Oncogene Proteins
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