Intrahepatic cholestasis of pregnancy resistant to both therapeutic plasma exchange and albumin dialysis.

Abstract

Intrahepatic cholestasis in pregnancy (ICP) represents, depending on its severity, a serious risk for the fetus. Those cases with unusually high bile acid levels may be resistant to pharmaceutical treatment and can be treated with plasma exchange or albumin dialysis. However, the success rate of these therapeutic options and the factors influencing therapeutic response are unknown. Furthermore, if these options fail to improve ICP and serum bile acid levels are very high (>200 μm/L), there are no clear recommendations when delivery should be planned. Here, we report a patient with severe ICP resistant to both therapeutic plasma exchange and albumin dialysis. Caesarean section was performed at 32 weeks of gestation followed by rapid remission of ICP.

• Authors: Massimiliano Lia, Thomas Berg, Laura Christina Weydandt, Holger Stepan
• Journal: BMJ case reports (BMJ Case Rep) Vol. 15 Issue 2 (Feb 08 2022) ISSN: 1757-790X [Electronic] England
• PMID: 35135789 (Publication Type: Case Reports, Journal Article)
• Copyright: © BMJ Publishing Group Limited 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

Chemical References

• Albumins

Topics

• Albumins
• Cesarean Section
• Cholestasis, Intrahepatic (therapy)
• Female
• Humans
• Plasma Exchange
• Pregnancy
• Pregnancy Complications (therapy)
• Renal Dialysis