MicroRNA miR-7 Is Essential for Post-stroke Functional Recovery.

Abstract

Transient focal ischemia induces a sustained downregulation of miR-7 leading to derepression of its target α-synuclein (α-Syn), which promotes neuronal death. We previously showed that treatment with miR-7 mimic prevents α-Syn induction and protects brain after stroke in rodents irrespective of age and sex. To further decipher the role of miR-7, we currently studied infarction and motor function in miR-7 double knockout mice (lack both miR-7a and miR-7b) subjected to focal ischemia. Adult miR-7-/- mice showed similar motor and cognitive functions to miR-7+/+ mice. However, when subjected to even a mild focal ischemia, the miR-7-/- mice showed exacerbated brain damage and worsened motor function compared with the miR-7+/+ mice. Replenishing miR-7 in miR-7-/- mice (IV injection of miR-7 mimic) restored miR-7 mediated neuroprotection and motor recovery, potentially by preventing α-Syn protein induction. Thus, we show that miR-7 is an essential miRNA in the brain that prevents α-Syn translation and the ensuing brain damage after stroke.

• Authors: Suresh L Mehta, Anil K Chokkalla, Saivenkateshkomal Bathula, Raghu Vemuganti
• Journal: Translational stroke research (Transl Stroke Res) Vol. 14 Issue 1 Pg. 111-115 (02 2023) ISSN: 1868-601X [Electronic] United States
• PMID: 35088373 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S., Research Support, N.I.H., Extramural)
• Copyright: © 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Chemical References

• MicroRNAs

Topics

• Mice
• Animals
• Stroke (genetics, metabolism)
• MicroRNAs (genetics, metabolism)
• Brain Ischemia (metabolism)
• Brain (metabolism)
• Mice, Knockout
• Mice, Inbred C57BL