Abstract | OBJECTIVE: METHODS: RESULTS: A total of 24 patients (18 boys) with mean age of 8.0 ± 3.0 y were enrolled. Urine volume significantly increased with combination therapy as compared to furosemide therapy (mean difference: 1.2 mL/kg/h; 95% CI: 0.8-1.65 mL/kg/h) (p < 0.001). Compared to therapy with furosemide alone, combination therapy resulted in significant reduction in body weight from 26.9 ± 10.3 kg to 24.8 ± 9.7 kg (p < 0.001). Estimated glomerular filtration rate did not change (p = 0.81) but serum sodium increased from 135.7 ± 3.3 mEq/L to 140.4 ± 4.8 mEq/L (p < 0.001) with combination therapy; 2 patients showed asymptomatic hypernatremia. CONCLUSION:
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Authors | Jitendra Meena, Pankaj Hari, Aditi Sinha, Arvind Bagga |
Journal | Indian journal of pediatrics
(Indian J Pediatr)
Vol. 89
Issue 7
Pg. 699-705
(07 2022)
ISSN: 0973-7693 [Electronic] India |
PMID | 35080742
(Publication Type: Journal Article)
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Copyright | © 2021. Dr. K C Chaudhuri Foundation. |
Chemical References |
- Diuretics
- Tolvaptan
- Furosemide
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Topics |
- Child
- Child, Preschool
- Diuretics
(therapeutic use)
- Drug Therapy, Combination
- Edema
(drug therapy, etiology)
- Furosemide
(adverse effects)
- Heart Failure
(complications, drug therapy)
- Humans
- Male
- Nephrotic Syndrome
(complications, drug therapy)
- Prospective Studies
- Tolvaptan
(adverse effects)
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