Intercalation-Activated Layered MoO3 Nanobelts as Biodegradable Nanozymes for Tumor-Specific Photo-Enhanced Catalytic Therapy.

Abstract

The existence of natural van der Waals gaps in layered materials allows them to be easily intercalated with varying guest species, offering an appealing strategy to optimize their physicochemical properties and application performance. Herein, we report the activation of layered MoO3 nanobelts via aqueous intercalation as an efficient biodegradable nanozyme for tumor-specific photo-enhanced catalytic therapy. The long MoO3 nanobelts are grinded and then intercalated with Na+ and H2 O to obtain the short Na+ /H2 O co-intercalated MoO3-x (NH-MoO3-x ) nanobelts. In contrast to the inert MoO3 nanobelts, the NH-MoO3-x nanobelts exhibit excellent enzyme-mimicking catalytic activity for generation of reactive oxygen species, which can be further enhanced by the photothermal effect under a 1064 nm laser irradiation. Thus, after bovine serum albumin modification, the NH-MoO3-x nanobelts can efficiently kill cancer cells in vitro and eliminate tumors in vivo facilitating with 1064 nm laser irradiation.

• Authors: Zhan Zhou, Yanlong Wang, Feng Peng, Fanqi Meng, Jiajia Zha, Lu Ma, Yonghua Du, Na Peng, Lufang Ma, Qinghua Zhang, Lin Gu, Wenyan Yin, Zhanjun Gu, Chaoliang Tan
• Journal: Angewandte Chemie (International ed. in English) (Angew Chem Int Ed Engl) Vol. 61 Issue 16 Pg. e202115939 (04 11 2022) ISSN: 1521-3773 [Electronic] Germany
• PMID: 35080098 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
• Copyright: © 2022 Wiley-VCH GmbH.

Chemical References

• Oxides
• Reactive Oxygen Species
• Water

Topics

• Catalysis
• Humans
• Neoplasms
• Oxides (chemistry)
• Reactive Oxygen Species
• Water