Abstract | OBJECTIVE: METHODS: The National Health and Nutritional Examination Survey (NHANES) 2003-16, nationally representative data were utilized for this study. A cross-sectional observational study was designed to assess the strength of the association between urinary PAH and CVDs. The NHANES survey used a stratified multistage probability sample strategy for obtaining representative samples. Logistic regression analysis was performed to evaluate the association between PAH and the prevalence of CVDs. RESULTS: In our study, the average ages of the three different PAHs tertiles were 42.56 ± 19.68, 42.21 ± 19.51, and 43.39 ± 17.99 years, respectively. A positive association was found between the second and third tertile of urinary PAH and increased prevalence of coronary heart disease (tertile-2: OR = 1.24, 95% CI = 1.09-1.42; tertile-3: OR = 1.97, 95% CI = 1.69-2.28), angina (tertile-2: OR = 1.3, 95% CI = 1.13-1.49; tertile-3: OR = 2.07, 95% CI = 1.76-2.42), heart attack (tertile-2: OR = 1.28, 95% CI = 1.12-1.47; tertile-3: OR = 1.71, 95% CI = 1.48-1.96) and stroke (tertile-2: OR = 1.17, 95% CI = 1.02-1.33; tertile-3: OR = 1.66, 95% CI = 1.43-1.93) in total participants, respectively, with p-values less than 0.05. CONCLUSION: In conclusion, this study found a positive association between urinary PAHs and the prevalence of various CVDs among the US population.
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Authors | Manthar Ali Mallah, Li Changxing, Mukhtiar Ali Mallah, Muhammad Naveed, Yang Liu, Sobia Noreen, He Xi, Wei Wang, Feifei Feng, Qiao Zhang |
Journal | Environmental research
(Environ Res)
Vol. 209
Pg. 112775
(06 2022)
ISSN: 1096-0953 [Electronic] Netherlands |
PMID | 35065070
(Publication Type: Journal Article, Observational Study)
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Copyright | Copyright © 2022 Elsevier Inc. All rights reserved. |
Chemical References |
- Biomarkers
- Polycyclic Aromatic Hydrocarbons
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Topics |
- Biomarkers
(urine)
- Cardiovascular Diseases
(epidemiology)
- Cross-Sectional Studies
- Humans
- Nutrition Surveys
- Polycyclic Aromatic Hydrocarbons
(urine)
- Surveys and Questionnaires
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