Liquid biopsy in lung cancer: significance in diagnostics, prediction, and treatment monitoring.

Abstract

Primary lung cancer is one of the most common malignant tumors in China. Approximately 60% of lung cancer patients have distant metastasis at the initial diagnosis, so it is necessary to find new tumor markers for early diagnosis and individualized treatment. Tumor markers contribute to the early diagnosis of lung cancer and play important roles in early detection and treatment, as well as in precision medicine, efficacy monitoring, and prognosis prediction. The pathological diagnosis of lung cancer in small biopsy specimens determines whether there are tumor cells in the biopsy and tumor type. Because biopsy is traumatic and the compliance of patients with multiple biopsies is poor, liquid biopsy has become a hot research direction. Liquid biopsies are advantageous because they are nontraumatic, easy to obtain, reflect the overall state of the tumor, and allow for real-time monitoring. At present, liquid biopsies mainly include circulating tumor cells, circulating tumor DNA, exosomes, microRNA, circulating RNA, tumor platelets, and tumor endothelial cells. This review introduces the research progress and clinical application prospect of liquid biopsy technology for lung cancer.

• Authors: Wen Li, Ji-Bin Liu, Li-Kun Hou, Fei Yu, Jie Zhang, Wei Wu, Xiao-Mei Tang, Feng Sun, Hai-Min Lu, Jing Deng, Jie Bai, Juan Li, Chun-Yan Wu, Qin-Lu Lin, Zhong-Wei Lv, Gao-Ren Wang, Geng-Xi Jiang, Yu-Shui Ma, Da Fu
• Journal: Molecular cancer (Mol Cancer) Vol. 21 Issue 1 Pg. 25 (01 20 2022) ISSN: 1476-4598 [Electronic] England
• PMID: 35057806 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: © 2022. The Author(s).

Chemical References

• Biomarkers, Tumor
• Circulating Tumor DNA

Topics

• Animals
• Biomarkers, Tumor
• Circulating Tumor DNA
• Clinical Decision-Making
• Disease Management
• Disease Susceptibility
• Exosomes
• High-Throughput Nucleotide Sequencing
• Humans
• Liquid Biopsy (methods, standards)
• Lung Neoplasms (diagnosis, etiology, therapy)
• Neoplastic Cells, Circulating (metabolism, pathology)
• Prognosis