Fluorescence Molecular Targeting of Colon Cancer to Visualize the Invisible.

Abstract

Colorectal cancer (CRC) is a common cause of cancer and cancer-related death. Surgery is the only curative modality. Fluorescence-enhanced visualization of CRC with targeted fluorescent probes that can delineate boundaries and target tumor-specific biomarkers can increase rates of curative resection. Approaches to enhancing visualization of the tumor-to-normal tissue interface are active areas of investigation. Nonspecific dyes are the most-used approach, but tumor-specific targeting agents are progressing in clinical trials. The present narrative review describes the principles of fluorescence targeting of CRC for diagnosis and fluorescence-guided surgery with molecular biomarkers for preclinical or clinical evaluation.

• Authors: Thinzar M Lwin, Michael A Turner, Siamak Amirfakhri, Hiroto Nishino, Robert M Hoffman, Michael Bouvet
• Journal: Cells (Cells) Vol. 11 Issue 2 (01 12 2022) ISSN: 2073-4409 [Electronic] Switzerland
• PMID: 35053365 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, U.S. Gov't, Non-P.H.S., Review)

Chemical References

• Biomarkers, Tumor
• Fluorescent Dyes

Topics

• Animals
• Biomarkers, Tumor (metabolism)
• Colonic Neoplasms (surgery, therapy)
• Fluorescence
• Fluorescent Dyes (chemistry)
• Humans
• Molecular Targeted Therapy