Hard-to-healing or nonhealing diabetic
wounds caused by
hyperglycemia,
bacterial infection and chronic
inflammation are becoming a challenge globally. In this study, a novel
hydrogel for diabetic wound healing composed of methacrylic
anhydride-modified
gelatin (GelMA)
hydrogel and mimicking neutrophil nanoparticles was originally created. The prepared GelMA
hydrogel has good sprayability and film-formation ability under blue light illumination (wavelength = 435-480 nm). Nanoparticles mimicking neutrophils belong to a double
enzyme system that are encapsulated in ZIF-8 nanoparticles, which can consume
glucose to produce HClO, ensuring a decrease in the
glucose concentration of the
wound and growth inhibition in bacteria. The
hydrogel also has excellent biocompatibility, which can promote the growth and proliferation of fibroblasts. More importantly, the
hydrogel can accelerate wound healing in type I diabetic rats owing to the downregulation of proinflammatory
cytokines, and the
wound with an area of 1 cm2 can be almost fully healed with no formation of the
scar on the 21st day, as verified by histochemistry and immunohistochemistry. All these combinations indicate its potential in diabetic
wound treatment.