Abstract | BACKGROUND: METHODS: We analyzed all coding exons and adjacent intronic regions of PLA2G1B in 416 German patients with non-alcoholic chronic pancreatitis (NACP) and 186 control subjects by direct DNA sequencing. RESULTS: We detected 2 frequent synonymous variants in exon 3: c.222T>C (p.Y74 = ) and c.294G>A (p.S98 = ). The genotype and allele frequencies of these variants were similar between patients and controls (c.222 TC: 9.6% in NACP vs. 9.7% in controls; c.222CC: 0.2% in NACP vs. 0% in controls; c.294 GA: 31.3% in NACP vs. 28.0% in controls; c.294AA: 2.4% in NACP vs. 1.1% in controls). All p-values were non-significant. In addition, we found one synonymous variant, c.138C>T (p.N46 = ) and one non-synonymous variant, c.244A>G (p.S82G), in a single case each. CONCLUSIONS: Our results suggest that genetic alterations in PLA2G1B do not predispose to the development of non-alcoholic chronic pancreatitis.
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Authors | Maren Ewers, Denise Epple, Peter Bugert, Jonas Rosendahl, Heiko Witt |
Journal | Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]
(Pancreatology)
Vol. 22
Issue 2
Pg. 244-247
(Mar 2022)
ISSN: 1424-3911 [Electronic] Switzerland |
PMID | 35031208
(Publication Type: Journal Article)
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Copyright | Copyright © 2022 IAP and EPC. Published by Elsevier B.V. All rights reserved. |
Chemical References |
- Group IB Phospholipases A2
- PLA2G1B protein, human
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Topics |
- Gene Frequency
- Genetic Testing
- Group IB Phospholipases A2
(genetics)
- Humans
- Pancreatitis, Alcoholic
(genetics)
- Pancreatitis, Chronic
(genetics)
- Sequence Analysis, DNA
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