Small-size (40 µm) Beads Loaded with Irinotecan in the Treatment of Patients with Colorectal Liver Metastases.

Abstract

PURPOSE:

The purpose of this study was to investigate survival outcomes and safety after chemoembolization using irinotecan-loaded small-size beads (DEB-IRI) in patients with colorectal liver metastases unresponsive to standard chemotherapy.

MATERIALS AND METHODS:

Between December 2013 and August 2019, fifty-five patients (32 males, median age 64.5 years) with pretreated colorectal liver metastases unresponsive to standard chemotherapy underwent 197 chemoembolization procedures (mean 3.6 ± 2.3 SD per patient). Thirty patients (30/55; 55%) had extrahepatic disease metastatic to the lungs, lymph nodes or peritoneum. Local tumor control was evaluated at 3, 6, 9 and 12 months. Median overall survival, survival rates at 1 and 2 year and adverse events were evaluated.

RESULTS:

Local tumor control was achieved in 32/55 (58%), 12/55 (22%), 4/55 (7%) and 2/55 (4%) patients at 3, 6, 9 and 12 months, respectively. Median overall survival was 9.9 months (95% CI: 6.2-14.2 months) with 1- and 2-year survival rates of 45% and 15%, respectively. A total of 30 (15%) G1-G3 treatment-related adverse events occurred across all embolization procedures. No severe treatment-related adverse events occurred.

CONCLUSION:

Chemoembolization using irinotecan-loaded small-size beads is a safe and effective procedure as a salvage treatment in patients with colorectal liver metastases, showing good results in terms of liver-specific progression free survival and overall survival.

• Authors: Giovanni Mauri, Duccio Rossi, Samuele Frassoni, Guido Bonomo, Nicola Camisassi, Paolo Della Vigna, Vincenzo Bagnardi, Daniele Maiettini, Gianluca Maria Varano, Maria Giulia Zampino, Franco Orsi
• Journal: Cardiovascular and interventional radiology (Cardiovasc Intervent Radiol) Vol. 45 Issue 6 Pg. 770-779 (Jun 2022) ISSN: 1432-086X [Electronic] United States
• PMID: 35029709 (Publication Type: Journal Article)
• Copyright: © 2021. Springer Science+Business Media, LLC, part of Springer Nature and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE).

Chemical References

• Irinotecan

Topics

• Chemoembolization, Therapeutic (methods)
• Colorectal Neoplasms (pathology)
• Humans
• Irinotecan
• Liver Neoplasms (drug therapy, secondary)
• Male
• Microspheres
• Middle Aged
• Survival Rate
• Treatment Outcome