ARID1A Is a Prognostic Biomarker and Associated with Immune Infiltrates in Hepatocellular Carcinoma.

Abstract

Objective:

ARID1A has been discovered as a potential cancer biomarker. But its role in hepatocellular carcinoma (HCC) is subject to considerable dispute.

Methods:

The relationship between ARID1A and clinical factors was investigated. Clinicopathological variables related to overall survival in HCC subjects were identified using Cox and Kaplan-Meier studies. The connection between immune infiltrating cells and ARID1A expression was investigated using the tumor Genome Atlas (TCGA) dataset for gene set enrichment analysis (GSEA). Finally, a cell experiment was used to confirm it.

Results:

The gender and cancer topography (T) categorization of HCC were linked to increased ARID1A expression. Participants with advanced levels of ARID1A expression had a worse prognosis than someone with lower levels. ARID1A was shown to be a risk indicator of overall survival on its own. ARID1A expression is inversely proportional to immune cell infiltration. In vitro, decreasing ARID1A expression substantially slowed the cell cycle and decreased HCC cell proliferation, migration, and invasion.

Conclusion:

The expression of ARID1A could be used to predict the outcome of HCC. It is closely related to tumor immune cell infiltration.

• Authors: Yuanyuan Feng, Xinfang Tang, Changcheng Li, Ying Su, Xiaoyu Wang, Ning Li, Anna Zhang, Feng Jiang, Chuyan Wu
• Journal: Canadian journal of gastroenterology & hepatology (Can J Gastroenterol Hepatol) Vol. 2022 Pg. 3163955 ( 2022) ISSN: 2291-2797 [Electronic] Egypt
• PMID: 35028302 (Publication Type: Journal Article)
• Copyright: Copyright © 2022 Yuanyuan Feng et al.

Chemical References

• ARID1A protein, human
• Biomarkers, Tumor
• DNA-Binding Proteins
• Transcription Factors

Topics

• Biomarkers, Tumor
• Carcinoma, Hepatocellular
• Cell Cycle
• DNA-Binding Proteins
• Humans
• Liver Neoplasms
• Prognosis
• Transcription Factors (genetics)