KGF-2 Regulates STAP-2-Mediated Signal Transducer and Activator of Transcription 3 Signaling and Reduces Skin Scar Formation.
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| Abstract |
Hypertrophic scar is a common complication of burns, skin trauma, and postoperative trauma, which involves excessive proliferation of fibroblasts and accumulation of a large amount of disorganized collagen fibers and extracellular matrix. KGF-2 plays important roles in the regulation of cellular homeostasis and wound healing. In this study, we investigated the effect and underlying mechanism of KGF-2 on scar formation after wound healing both in vitro and in vivo. We show that KGF-2 attenuates mechanical stress-induced scar formation while promoting wound healing. Mechanistically, KGF-2 inhibits STAP-2 expression and signal transducer and activator of transcription 3 activation, leading to significantly reduced collagen I and collagen III levels. Our results provide an insight into the role of KGF-2 in wound healing and scar formation and the therapeutic potential for reducing scarring while promoting wound healing.
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| Authors | Qingde Zhou, Jianxiang Gong, Jianing Bi, Xuanxin Yang, Li Zhang, Chao Lu, Lijia Li, Min Chen, Jianqiu Cai, Rongshuai Yang, Xiaokun Li, Zhiming Li, Xiaojie Wang |
| Journal | The Journal of investigative dermatology (J Invest Dermatol) Vol. 142 Issue 7 Pg. 2003-2013.e5 (07 2022) ISSN: 1523-1747 [Electronic] United States |
| PMID | 34999107 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
| Copyright | Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved. |
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