Therapeutic carrier based on solanesol and hyaluronate for synergistic tumor treatment.

Abstract

The administration of nanodrugs can lead to metabolism related systemic toxicity due to the use of inert carriers in large quantities. Carrier materials that offer therapeutic effects are therefore a promising means of addressing this limitation. Herein, a hyaluronate-based nanocarrier was prepared from hyaluronic acid (HA) and solanesol. Solanesyl thiosalicylate (STS) derived from solanesol has certain antitumor effects and was used to modify HA. The conjugate (HA-STS) self-assembled into nanoparticles acting as a drug carrier. The synthesis of the conjugates was confirmed by 1H NMR spectroscopy. Doxorubicin (DOX) was loaded into the HA-STS nanoparticles with a relatively high content of 6.0%. pH-sensitive drug release behavior was achieved by introducing a hydroazone bond between STS and HA. A cytotoxicity assay indicated that the blank nanoparticles had an antitumor effect, which was enhanced by loading with an additional drug. Moreover, in vivo antitumor experiments indicated that the HA-STS-DOX showed superior tumor inhibition compared with free DOX, as well as lower cardiotoxicity and hepatotoxicity, demonstrating the advantages of the bioactive drug vehicles in cancer therapy.

• Authors: Mengying Zhang, Huimin Yu, Jinglu Hu, Zhengyu Zhao, Lei Liu, Gaomin Yang, Tingli Wang, Guang Han, Shiyong Song
• Journal: International journal of biological macromolecules (Int J Biol Macromol) Vol. 201 Pg. 20-28 (Mar 15 2022) ISSN: 1879-0003 [Electronic] Netherlands
• PMID: 34998870 (Publication Type: Journal Article)
• Copyright: Copyright © 2021. Published by Elsevier B.V.

Chemical References

• Drug Carriers
• Terpenes
• Doxorubicin
• Hyaluronic Acid
• solanesol

Topics

• Doxorubicin
• Drug Carriers (chemistry)
• Drug Delivery Systems (methods)
• Drug Liberation
• Humans
• Hyaluronic Acid (chemistry)
• Nanoparticles (chemistry)
• Neoplasms (drug therapy)
• Terpenes (chemistry)