Correlation Between Zinc Nutritional Status with Serum Zonulin and Gastrointestinal Symptoms in Diarrhea-Predominant Irritable Bowel Syndrome: A Case-Control Study.

Abstract

BACKGROUND:

Zinc is known to have a critical role in the maintenance of intestinal homeostasis, immune cells, and anti-diarrheal and anti-inflammatory actions.

AIMS:

The aim of this study was to evaluate the correlation between zinc status with serum zonulin and gastrointestinal symptoms in diarrhea-predominant patients with irritable bowel syndrome (IBS-D).

METHODS:

This case-control study included 61 newly diagnosed IBS-D patients and 61 healthy matched controls. Dietary zinc intake, serum zinc, and zonulin levels were measured. IBS severity was evaluated using the IBS severity score system (IBS-SSS) questionnaire.

RESULTS:

Serum zinc levels were lower in the IBS-D group compared with the controls (p = 0.001). Serum zinc was negatively correlated with serum zonulin in IBS-D patients (r = - 0.271; p = 0.035). Also, a reverse association between the serum zinc and odds of IBS-D was found [OR = 0.979; 95% CI (0.966-0.992)].

CONCLUSIONS:

Our results suggest that zinc may have a role in the pathogenesis of IBS. However, clinical trial studies are warranted to evaluate this finding.

• Authors: Mahsa Rezazadegan, Maryam Soheilipour, Mohammad Javad Tarrahi, Reza Amani
• Journal: Digestive diseases and sciences (Dig Dis Sci) Vol. 67 Issue 8 Pg. 3632-3638 (08 2022) ISSN: 1573-2568 [Electronic] United States
• PMID: 34993680 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Chemical References

• Haptoglobins
• Protein Precursors
• zonulin
• Zinc

Topics

• Case-Control Studies
• Haptoglobins
• Humans
• Irritable Bowel Syndrome (diagnosis)
• Nutritional Status
• Protein Precursors
• Zinc