The clinical efficacy of
polymyxins in severe
infection caused by
carbapenem resistant organism (CRO) has gradually been recognized, and the course of treatment is generally 2 to 4 weeks. The most common complications after
intravenous injection are nephrotoxicity and neurotoxicity, however, there are few reports on the efficacy and safety of the long course use of
polymyxins. A patient with
carbapenem resistant Acinetobacter baumannii (CRAB)
infection after neurosurgery was admitted to the department of neurosurgical intensive care unit (NICU) of Lanzhou University Second Hospital. As the family refused the excision of
brain abscess and Ommaya reservoir placement,
polymyxin B was given intravenous (3.0 mg×kg-1×d-1) combined with intrathecal (5 mg once daily) injection, and high-dose
sulbactam (8 g/d) was intravenously injected for anti-
infection therapy. Finally, the
brain abscess was absorbed and the patient was successfully cured. The total course of
polymyxin B was 69 days with a cumulative dosage of 7 500 mg. There were no complications such as
polymyxin-related nephrotoxicity and neurotoxicity during the period, and no symptoms of respiratory inhibition or neuromuscular blockage were observed, but
polymyxin-related skin pigmentation appeared about 1 month after
intravenous administration of
polymyxins B, which subsided after
drug withdrawal. It is suggested that long course of
polymyxins B is safe and effective for intracranial
infection caused by CRAB.