Hydrogel wound dressings with good flexibility and adhesiveness to resist deformation during
wound movement are urgently needed in clinical application. In this work, the
hydrogels based on
poly (acrylic acid) and
N-hydroxysuccinimide grafted
hyaluronic acid (PAA/HA-NHS) with good elasticity and adhesiveness were prepared by chemical cross-linking and hydrogen bonding. The elastic and adhesive properties within the PAA
hydrogels could reach a balance by adjusting the concentration of
potassium persulfate (KPS) and
N, N'-methylenebisacrylamide (MBA). Subsequently, HA-NHS was incorporated into the PAA
hydrogel system. The mechanical test revealed that the elongation at break and interfacial toughness of the PAA/HA-NHS
hydrogels could reach 265.79 ± 21.93% and 52.88 ± 3.51 J/m2, respectively. In addition, the
hydrogels possess a connected porous network and well water absorption ability (with porosity of 51.90 ± 0.11% and swelling ratio in wet state of 122.17 ± 2.78%). In vitro experiment demonstrates that the PAA/HA-NHS
hydrogels exhibit nontoxic and cell in-adhesive properties. The PAA/HA-NHS
hydrogels could cover the
wound spots directly, stretch with the skin movement and gently remove from the
wound tissue due to the suitable adhesiveness and poor cell adhesion. In conclusion, the PAA/HA-NHS
hydrogels show great application value in the field of
wound dressing.