M2 macrophage microvesicle-inspired nanovehicles improve accessibility to cancer cells and cancer stem cells in tumors.

Abstract

Cancer cells and cancer stem cells (CSCs) are the major players of cancer malignancy and metastasis, but they are extremely difficult to access. Inspired by the vital role of macrophages and microvesicle-mediated cell-cell communication in tumors, we herein designed M2 macrophage microvesicle-inspired nanovehicle of cabazitaxel (M-CFN) to promote accessibility to cancer cells and CSCs in tumors. In the 4T1 tumor model, M-CFN flexibly permeated the tumor mass, accessed cancer cells and CD90-positive cells, and significantly promoted their entry into CSC fractions in tumors. Moreover, M-CFN treatment profoundly eliminated aldehyde dehydrogenase (ALDH)-expressing CSCs in 4T1 and MCF-7 tumors, produced notable depression of tumor growth and caused 93.86% suppression of lung metastasis in 4T1 models. Therefore, the M2 macrophage microvesicle-inspired nanovehicle provides an encouraging strategy to penetrate the tumor tissues and access these insult cells in tumors for effective cancer therapy.

• Authors: Yuqi Wang, Xiang Gong, Jie Li, Hong Wang, Xiaoxuan Xu, Yao Wu, Jiaoying Wang, Siling Wang, Yaping Li, Zhiwen Zhang
• Journal: Journal of nanobiotechnology (J Nanobiotechnology) Vol. 19 Issue 1 Pg. 397 (Nov 27 2021) ISSN: 1477-3155 [Electronic] England
• PMID: 34838042 (Publication Type: Journal Article)
• Copyright: © 2021. The Author(s).

Chemical References

• Antineoplastic Agents
• Taxoids
• cabazitaxel

Topics

• Animals
• Antineoplastic Agents (chemistry, pharmacokinetics, pharmacology)
• Cell Survival (drug effects)
• Cell-Derived Microparticles (chemistry, metabolism)
• Drug Delivery Systems (methods)
• Female
• Humans
• Lung Neoplasms (metabolism)
• MCF-7 Cells
• Macrophages (cytology)
• Mice
• Mice, Inbred BALB C
• Nanostructures (chemistry)
• Neoplastic Stem Cells (metabolism)
• Taxoids (chemistry, pharmacokinetics, pharmacology)