Clearance of Lormetazepam, Midazolam, and Their Conjugated Metabolites by Continuous Venovenous Hemofiltration During Prolonged Sedation in Critically Ill Patients With COVID-19-Associated Acute Respiratory Distress Syndrome.

• Authors: Kimberly N Shudofsky, Paddy K C Janssen, Norbert Foudraine, Jos L M L le Noble
• Journal: Journal of clinical pharmacology (J Clin Pharmacol) Vol. 62 Issue 4 Pg. 568-570 (04 2022) ISSN: 1552-4604 [Electronic] England
• PMID: 34793610 (Publication Type: Letter)

Chemical References

• Hypnotics and Sedatives
• lormetazepam
• Lorazepam
• Midazolam

Topics

• Aged
• COVID-19 (complications)
• Continuous Renal Replacement Therapy
• Critical Illness (therapy)
• Deep Sedation
• Humans
• Hypnotics and Sedatives (metabolism, pharmacokinetics, therapeutic use)
• Lorazepam (analogs & derivatives, metabolism, pharmacokinetics, therapeutic use)
• Male
• Midazolam (metabolism, pharmacokinetics, therapeutic use)
• Middle Aged
• Respiratory Distress Syndrome (complications, drug therapy)
• COVID-19 Drug Treatment