Abstract | BACKGROUND: OBJECTIVE: To assess patient preference between docetaxel and cabazitaxel among men who received one or more doses of each taxane and did not experience progression after the first taxane. DESIGN, SETTING, AND PARTICIPANTS: OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: The primary endpoint was patient preference, assessed via a dedicated questionnaire after the second taxane. Secondary endpoints included reasons for patient preference, prostate-specific antigen response, radiological progression-free survival, and overall survival. This clinical trial is registered at ClinicalTrials.gov as NCT02044354. RESULTS AND LIMITATIONS: Of 195 men randomized, 152 met the prespecified modified intent-to-treat criteria for analysis. Overall, 66 patients (43%) preferred cabazitaxel, 40 (27%) preferred docetaxel, and 46 (30%) had no preference (p = 0.004, adjusted for treatment period effect). More patients preferred treatment period 1 (43%, 95% confidence interval [CI] 36-52%) versus period 2 (27%, 95% CI 20-34%). Patient preference for cabazitaxel was mainly related to less fatigue (72%), better quality of life (64%), and other adverse events ( hair loss, pain, nail disorders, edema). Adverse events were consistent with the known safety profile of each drug. CONCLUSIONS: PATIENT SUMMARY:
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Authors | Giulia Baciarello, Remy Delva, Gwenaelle Gravis, Youssef Tazi, Philippe Beuzeboc, Marine Gross-Goupil, Emmanuelle Bompas, Florence Joly, Charlotte Greilsamer, Thierry Nguyen Tan Hon, Philippe Barthelemy, Stephane Culine, Jean Francois Berdah, Mathilde Deblock, Raffaele Ratta, Aude Flechon, Caroline Cheneau, Aline Maillard, Geraldine Martineau, Isabelle Borget, Karim Fizazi, Groupe d’Etude des Tumeurs Uro-Genitales (GETUG). |
Journal | European urology
(Eur Urol)
Vol. 81
Issue 3
Pg. 234-240
(Mar 2022)
ISSN: 1873-7560 [Electronic] Switzerland |
PMID | 34789394
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2021 European Association of Urology. Published by Elsevier B.V. All rights reserved. |
Chemical References |
- Taxoids
- Docetaxel
- cabazitaxel
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Topics |
- Antineoplastic Combined Chemotherapy Protocols
(adverse effects)
- Disease-Free Survival
- Docetaxel
(therapeutic use)
- Fatigue
(chemically induced)
- Female
- Humans
- Male
- Patient Preference
- Prostatic Neoplasms, Castration-Resistant
(pathology)
- Quality of Life
- Taxoids
(adverse effects)
- Treatment Outcome
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