circRNA is a potential target for cardiovascular diseases treatment.

Abstract

Circular RNAs (circRNAs), a novel class of endogenous noncoding RNA, are characterized by their covalently closed-loop structures without a 5' cap or a 3' poly(A) tail. With the evolution of high-throughput sequencing technology and bioinformatics, an increasing number of circRNAs have been discovered, and their functions were highlighted. Cardiovascular diseases (CVDs) have become the world's leading killers, with serious impacts on human health. Although significant progress has been made in clarifying the development of CVDs from the molecular to the cellular level, CVDs remain one of the leading causes of death in humans. circRNAs mainly function as a "sponge" to absorb microRNAs, which results in the positive control of downstream proteins. They play important regulatory roles in the development of CVDs. This paper reviews current knowledge on the biogenesis, detection and validation, translation, translocation and degradation, and general functions of circRNAs, with a focus on their roles in CVDs.

• Authors: Jie Ju, Ya-Nan Song, Xin-Zhe Chen, Tao Wang, Cui-Yun Liu, Kun Wang
• Journal: Molecular and cellular biochemistry (Mol Cell Biochem) Vol. 477 Issue 2 Pg. 417-430 (Feb 2022) ISSN: 1573-4919 [Electronic] Netherlands
• PMID: 34780000 (Publication Type: Journal Article, Review)
• Copyright: © 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Chemical References

• MicroRNAs
• RNA, Circular

Topics

• Cardiovascular Diseases (genetics, metabolism, therapy)
• Computational Biology
• High-Throughput Nucleotide Sequencing
• Humans
• MicroRNAs (genetics, metabolism)
• RNA, Circular (genetics, metabolism)