Hepatoblastoma as the most prevalent hepatic
malignancy in children, its etiology remains unclear.
N6-Methyladenosine (m6A) modification which can modify various physiological processes, plays a critical role in
tumorigenesis.
Methyltransferase-like 14 (METTL14), an important component of the
m6A methyltransferase complex, remains elusive during
hepatoblastoma occurrence and development. We explored the relationship between METTL14 gene polymorphisms (rs1064034 T > A, rs298982 G > A, rs62328061 A > G, rs9884978 G > A, and rs4834698 T > C) and
hepatoblastoma susceptibility from 313 patients and 1446 controls. The role of METTL14 polymorphisms in
hepatoblastoma was evaluated by odds ratios (
ORs) and 95% confidence intervals (CIs). Of the included subjects, 308 patients and 1444 controls were successfully genotyped. We did not find any significant correlation between the risk of
hepatoblastoma and the five potentially functional METTL14 polymorphisms individually. However, the presence of 4-5 risk genotypes exhibited a significant increased
hepatoblastoma risk (adjusted OR = 1.32, 95% CI = 1.03-1.69, P = 0.031) compared to those carriers with 0-3 risk genotypes. Furthermore, the stratified analysis demonstrated that the rs1064034 AA genotype, rs62328061 AG/GG genotypes, rs4834698 TC/CC genotypes, and 4-5 risk genotypes were related to
hepatoblastoma susceptibility in certain subgroups. The expression quantitative trait loci (eQTL) analysis revealed that rs1064034 T > A and rs4834698 T > C were correlated with the expression levels of METTL14 and its surrounding genes. Prospectively, these findings suggested that METTL14 polymorphisms may correlation with
hepatoblastoma susceptibility and provide a fresh insight into the genetic underpinnings of
m6A modification in
hepatoblastoma.