Equipping Cancer Cell Membrane Vesicles with Functional DNA as a Targeted Vaccine for Cancer Immunotherapy.

Abstract

By inducing tumor-specific immune responses, tumor vaccines have recently aroused great research interest. Herein, we design a targeted nanovaccine by equipping cell membrane vesicles (CMVs) harvested from tumor cells with functional DNA including CpG oligonucleotide, an agonist for toll-like receptor 9, as well as an aptamer targeting the dendritic cell (DC)-specific intercellular adhesion molecule (ICAM)-3 grabbing nonintegrin (DC-SIGN) receptor overexpressed on DCs. Such DNA-modified CMVs could target DCs and further stimulate their maturation. Notably, our nanovaccines could trigger robust antitumor immune responses to effective delay the tumor growth. Moreover, the combination of CMV-based nanovaccines with an immune checkpoint blockade could result in improved therapeutic responses by eliminating the majority of the tumors as well as long-term immune memory to prevent tumor recurrence. Therefore, by simply assembling functional DNA on CMVs harvested from tumor cells, we propose a general platform of DC-targeted personalized cancer vaccines for effective and specific cancer immunotherapy.

• Authors: Bo Liu, Yu Yang, Yu Chao, Zhisheng Xiao, Jialu Xu, Chunjie Wang, Ziliang Dong, Linqian Hou, Qiaofeng Li, Zhuang Liu
• Journal: Nano letters (Nano Lett) Vol. 21 Issue 22 Pg. 9410-9418 (11 24 2021) ISSN: 1530-6992 [Electronic] United States
• PMID: 34730968 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cancer Vaccines
• DNA

Topics

• Cancer Vaccines (therapeutic use)
• Cell Membrane
• DNA (metabolism)
• Dendritic Cells
• Humans
• Immunotherapy
• Neoplasms (metabolism, therapy)