Abstract | Background: Aim: Methods: The study included 14 dogs diagnosed with advanced pulmonary edema with MI at two facilities. In all cases, high-dose loop diuretics ( torsemide; 0.78-4 mg/kg/day) did not improve pulmonary edema. The results of the echocardiography and renal function tests before and after the administration of HTCZ (0.2-0.84 mg/kg/day) in addition to torsemide were statistically compared. Results: The echocardiographic data demonstrated significant improvement in relation to cardiac stress; left atrium to the aorta ratio, normalized left ventricular internal dimension in diastole, and E wave velocity (m/s) after HTCZ administration. However, blood urea nitrogen and creatinine levels increased, and potassium levels decreased, indicating a decline in renal function following HTCZ administration. Conclusion: This study suggests that the administration of HTCZ in combination with loop diuretics may be beneficial during advanced heart failure due to MI in dogs. The results can also be extended to patients who are resistant to loop diuretics, resulting in the improvement of cardiac function. However, as the combination of HTCZ and loop diuretics can deteriorate renal function, caution should be exercised prior to making recommendations regarding its use, and renal function should be monitored.
|
Authors | Koji Iwanaga, Ryuji Araki, Mitsuhiro Isaka |
Journal | Open veterinary journal
(Open Vet J)
2021 Jul-Sep
Vol. 11
Issue 3
Pg. 342-345
ISSN: 2218-6050 [Electronic] Libya |
PMID | 34722194
(Publication Type: Journal Article)
|
Chemical References |
- Sodium Potassium Chloride Symporter Inhibitors
- Hydrochlorothiazide
|
Topics |
- Animals
- Dog Diseases
(drug therapy)
- Dogs
- Heart Failure
(drug therapy, veterinary)
- Hydrochlorothiazide
(therapeutic use)
- Retrospective Studies
- Sodium Potassium Chloride Symporter Inhibitors
|