Abstract | BACKGROUND: METHODS: From January 2002 to December 2018, pediatric patients with ALL treated at National Taiwan University Hospital were enrolled in this study. The diagnosis of AAP was based on the criteria of the Ponte di Legno Toxicity Working Group. RESULTS: Of the 353 patients enrolled in this study, 14 (4.0%) developed AAP. The incidence of AAP in ALL patients was significantly higher after treatment with the 2013 protocol compared with the 2002 protocol of the Taiwan Pediatric Oncology Group (9.5% vs. 1.3%). Multivariate analysis showed that a high peak L-Asp dose intensity (>45,000 U/m2/month) and older age at diagnosis (>6.8 years) were independently predictive of AAP development. CONCLUSIONS: The incidence of acute pancreatitis in childhood ALL was correlated more strongly with the peak dose intensity than with the cumulative dose of L-Asp. These results could be used to reduce the treatment-related complications of ALL. IMPACT:
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Authors | Chi-Bo Chen, Hsiu-Hao Chang, Shu-Wei Chou, Yung-Li Yang, Meng-Yao Lu, Shiann-Tarng Jou, Huey-Ling Chen, Yen-Hsuan Ni, Dong-Tsamn Lin, Mei-Hwei Chang, Jia-Feng Wu |
Journal | Pediatric research
(Pediatr Res)
Vol. 92
Issue 2
Pg. 459-465
(08 2022)
ISSN: 1530-0447 [Electronic] United States |
PMID | 34718353
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2021. The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc. |
Chemical References |
- Antineoplastic Agents
- Asparaginase
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Topics |
- Acute Disease
- Antineoplastic Agents
- Asparaginase
(adverse effects)
- Child
- Humans
- Pancreatitis
(chemically induced, complications, epidemiology)
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
(complications, drug therapy)
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