Therapeutic effect of baicalin on inflammatory bowel disease: A review.

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE:

Baicalin (BI) is an important biologically active flavonoid isolated from the root of Scutellaria radix (Huang Qin). Traditionally Scutellaria radix was the common drug of dysentery. As the main flavonoid compound, there is a distribution tendency of baicalin to the intestinal tract and it has a protective effect on the gastrointestinal tract.

AIM OF THE REVIEW:

This review aims to compile up-to-date and comprehensive information on the efficacy of baicalin in vitro and in vivo, about treating inflammatory bowel disease. Relevant information on the therapeutic potential of baicalin against inflammatory bowel disease was collected from the Web of Science, Pubmed and so on. Additionally, a few books and magazines were also consulted to get the important information.

RESULTS:

The mechanisms of baicalin against inflammatory bowel disease mainly include anti-inflammation, antioxidant, immune regulation, maintenance of intestinal barrier, maintenance of intestinal flora balance. Also, BI can relieve parts of extraintestinal manifestations (EIMs), and prevent colorectal cancer.

CONCLUSION:

Baicalin determined the promising therapeutic prospects as potential supplementary medicines for the treatment of IBD.

• Authors: Xian Wang, Long Xie, Jiaying Long, Kai Liu, Jing Lu, Youdan Liang, Yi Cao, Xiaolin Dai, Xiaofang Li
• Journal: Journal of ethnopharmacology (J Ethnopharmacol) Vol. 283 Pg. 114749 (Jan 30 2022) ISSN: 1872-7573 [Electronic] Ireland
• PMID: 34666140 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2021 Elsevier B.V. All rights reserved.

Chemical References

• Anti-Inflammatory Agents
• Antioxidants
• Flavonoids
• baicalin

Topics

• Animals
• Anti-Inflammatory Agents (isolation & purification, pharmacology)
• Antioxidants (isolation & purification, pharmacology)
• Flavonoids (isolation & purification, pharmacology)
• Humans
• Inflammatory Bowel Diseases (drug therapy, physiopathology)
• Scutellaria baicalensis (chemistry)