Greener Synthesis of Pristane by Flow Dehydrative Hydrogenation of Allylic Alcohol Using a Packed-Bed Reactor Charged by Pd/C as a Single Catalyst.

Abstract

Our previous work established a continuous-flow synthesis of pristane, which is a saturated branched alkane obtained from a Basking Shark. The dehydration of an allylic alcohol that is the key to a tetraene was carried out using a packed-bed reactor charged by an acid-silica catalyst (HO-SAS) and flow hydrogenation using molecular hydrogen via a Pd/C catalyst followed. The present work relies on the additional propensity of Pd/C to serve as an acid catalyst, which allows us to perform a flow synthesis of pristane from the aforementioned key allylic alcohol in the presence of molecular hydrogen using Pd/C as a single catalyst, which is applied to both dehydration and hydrogenation. The present one-column-two-reaction-flow system could eliminate the use of an acid catalyst such as HO-SAS and lead to a significant simplification of the production process.

• Authors: Takayoshi Kasakado, Yuki Hirobe, Akihiro Furuta, Mamoru Hyodo, Takahide Fukuyama, Ilhyong Ryu
• Journal: Molecules (Basel, Switzerland) (Molecules) Vol. 26 Issue 19 (Sep 27 2021) ISSN: 1420-3049 [Electronic] Switzerland
• PMID: 34641390 (Publication Type: Journal Article)