Prognostic significance of receptor expression discordance between primary and recurrent breast cancers: a meta-analysis.

Abstract

PURPOSE:

This meta-analysis aimed to investigate whether receptor (estrogen receptor [ER], progesterone receptor [PR], and human epidermal growth factor receptor 2 [HER2]) discordances between primary and recurrent breast cancers affect patients' survival.

METHODS:

Search terms contained ER, PR, and HER2 status details in both primary and recurrent tumors (local recurrence or distant metastasis) in addition to survival outcome data (overall survival [OS] or post-recurrence survival [PRS]).

RESULTS:

Loss of ER or PR in recurrent tumors was significantly associated with shorter OS as compared with receptor-positive concordance (hazard ratio [HR], 1.67; 95% confidence interval [% CI] 1.37-2.04; p < 0.00001 and HR, 1.45; 95% CI 1.21-1.75; p < 0.0001, respectively). Similar trends were observed in groups with only distant metastasis. Gain of ER was a significant predictor of longer PRS as compared with receptor-negative concordance (HR, 0.76; 95% CI 0.59-0.97; p = 0.03). Gain of PR was not a significant predictor of longer survival compared with receptor-negative concordance, but it could be related to better OS at distant metastasis. Both HER2 of loss and gain could be related to poor outcomes.

CONCLUSION:

This meta-analysis showed that receptor conversion in recurrent tumors may affect patient survival as compared with receptor concordance.

• Authors: Sho Shiino, Graham Ball, Binafsha M Syed, Sasagu Kurozumi, Andrew R Green, Hitoshi Tsuda, Shin Takayama, Akihiko Suto, Emad A Rakha
• Journal: Breast cancer research and treatment (Breast Cancer Res Treat) Vol. 191 Issue 1 Pg. 1-14 (Jan 2022) ISSN: 1573-7217 [Electronic] Netherlands
• PMID: 34613502 (Publication Type: Journal Article, Meta-Analysis, Review)
• Copyright: © 2021. The Author(s).

Chemical References

• Biomarkers, Tumor
• Receptors, Estrogen
• Receptors, Progesterone
• Receptor, ErbB-2

Topics

• Biomarkers, Tumor (genetics)
• Breast Neoplasms (genetics)
• Female
• Gene Expression
• Humans
• Neoplasm Recurrence, Local
• Prognosis
• Receptor, ErbB-2 (genetics)
• Receptors, Estrogen (genetics)
• Receptors, Progesterone (genetics)