[Complete response after neoadjuvant therapy : How certain is the pathology?]

Abstract

Histopathologic evaluation of tumors after neoadjuvant therapy is performed by tumor regression grading (TRG) systems, which reflect the proportion of vital residual primary tumor in relation to the previous total tumor. The World Health Organization (WHO) tumor grading is replaced by TRG in tumor classification. The histopathological work-up of a tumor is based on the criteria of the TNM classification even after neoadjuvant therapy. A uniform TRG does not exist. For various tumors TRGs based on the tumor entity have been established, consisting of a 3-stage or 5‑stage grading system. Complete histopathological tumor regression is only present if no vital tumor cells are detectable in the histopathological examination of the primary surgical specimens (primary tumor and accompanying locoregional lymph nodes) and there are no distant metastases.

• Authors: Iris Tischoff, Andrea Tannapfel
• Journal: Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen (Chirurg) Vol. 93 Issue 2 Pg. 115-122 (Feb 2022) ISSN: 1433-0385 [Electronic] Germany
• Vernacular Title: Komplettresponse nach neoadjuvanter Therapie : Wie sicher ist die Pathologie?
• PMID: 34613440 (Publication Type: Journal Article, Review)
• Copyright: © 2021. Springer Medizin Verlag GmbH, ein Teil von Springer Nature.

Topics

• Lymph Nodes
• Neoadjuvant Therapy
• Neoplasm Grading
• Neoplasm Staging
• Prognosis
• Remission Induction
• Retrospective Studies
• Treatment Outcome